Question: how has your work developed over the years?

Amy Grayson answered on 15 Jun 2017:

Good question Brooke!

I have only started working on this research project on bone marrow cancers in September 2016 and since then we have made some great progress looking at the mutations which cause the three different types of bone marrow cancers. At the start of my PhD, there were lots of questions about how one mutation in the same place in our DNA can cause 3 very different diseases as the three bone marrow cancers I am looking at all have the same mutation in our DNA but people can develop any of the three different cancers. Since then, we have been comparing the DNA of healthy cells to DNA of bone marrow cancer cells and believe the cancers may develop as an accumulation of a few different mutations and my experiments show this is possible. My research now is to find out precisely where these other mutations are and how they are different in each of the three types of cancers I am looking at!